diff --git a/.pnp.cjs b/.pnp.cjs
index 0421c3bcae..215bbb266d 100755
--- a/.pnp.cjs
+++ b/.pnp.cjs
@@ -1036,7 +1036,7 @@ function $$SETUP_STATE(hydrateRuntimeState, basePath) {
       ],\
       [\
         "cosmjs-types",\
-        "npm:0.5.2"\
+        "npm:0.6.0"\
       ],\
       [\
         "cross-spawn",\
@@ -3232,7 +3232,7 @@ function $$SETUP_STATE(hydrateRuntimeState, basePath) {
             ["axios", "npm:0.21.4"],\
             ["babylon", "npm:6.18.0"],\
             ["chalk", "npm:4.1.2"],\
-            ["cosmjs-types", "npm:0.5.2"],\
+            ["cosmjs-types", "npm:0.6.0"],\
             ["diff", "npm:4.0.2"],\
             ["eslint", "npm:7.26.0"],\
             ["eslint-config-prettier", "virtual:4f1584ad4aba8733a24be7c8aebbffafef25607f2d00f4b314cf96717145c692763628a31c2b85d4686fbb091ff21ebffa3cc337399c042c19a32b9bdb786464#npm:8.3.0"],\
@@ -3278,7 +3278,7 @@ function $$SETUP_STATE(hydrateRuntimeState, basePath) {
             ["@types/pako", "npm:1.0.1"],\
             ["@typescript-eslint/eslint-plugin", "virtual:4f1584ad4aba8733a24be7c8aebbffafef25607f2d00f4b314cf96717145c692763628a31c2b85d4686fbb091ff21ebffa3cc337399c042c19a32b9bdb786464#npm:5.13.0"],\
             ["@typescript-eslint/parser", "virtual:4f1584ad4aba8733a24be7c8aebbffafef25607f2d00f4b314cf96717145c692763628a31c2b85d4686fbb091ff21ebffa3cc337399c042c19a32b9bdb786464#npm:5.13.0"],\
-            ["cosmjs-types", "npm:0.5.2"],\
+            ["cosmjs-types", "npm:0.6.0"],\
             ["eslint", "npm:7.26.0"],\
             ["eslint-config-prettier", "virtual:4f1584ad4aba8733a24be7c8aebbffafef25607f2d00f4b314cf96717145c692763628a31c2b85d4686fbb091ff21ebffa3cc337399c042c19a32b9bdb786464#npm:8.3.0"],\
             ["eslint-import-resolver-node", "npm:0.3.4"],\
@@ -3651,7 +3651,7 @@ function $$SETUP_STATE(hydrateRuntimeState, basePath) {
             ["@types/node", "npm:15.9.0"],\
             ["@typescript-eslint/eslint-plugin", "virtual:4f1584ad4aba8733a24be7c8aebbffafef25607f2d00f4b314cf96717145c692763628a31c2b85d4686fbb091ff21ebffa3cc337399c042c19a32b9bdb786464#npm:5.13.0"],\
             ["@typescript-eslint/parser", "virtual:4f1584ad4aba8733a24be7c8aebbffafef25607f2d00f4b314cf96717145c692763628a31c2b85d4686fbb091ff21ebffa3cc337399c042c19a32b9bdb786464#npm:5.13.0"],\
-            ["cosmjs-types", "npm:0.5.2"],\
+            ["cosmjs-types", "npm:0.6.0"],\
             ["eslint", "npm:7.26.0"],\
             ["eslint-config-prettier", "virtual:4f1584ad4aba8733a24be7c8aebbffafef25607f2d00f4b314cf96717145c692763628a31c2b85d4686fbb091ff21ebffa3cc337399c042c19a32b9bdb786464#npm:8.3.0"],\
             ["eslint-import-resolver-node", "npm:0.3.4"],\
@@ -3752,7 +3752,7 @@ function $$SETUP_STATE(hydrateRuntimeState, basePath) {
             ["@types/node", "npm:15.9.0"],\
             ["@typescript-eslint/eslint-plugin", "virtual:4f1584ad4aba8733a24be7c8aebbffafef25607f2d00f4b314cf96717145c692763628a31c2b85d4686fbb091ff21ebffa3cc337399c042c19a32b9bdb786464#npm:5.13.0"],\
             ["@typescript-eslint/parser", "virtual:4f1584ad4aba8733a24be7c8aebbffafef25607f2d00f4b314cf96717145c692763628a31c2b85d4686fbb091ff21ebffa3cc337399c042c19a32b9bdb786464#npm:5.13.0"],\
-            ["cosmjs-types", "npm:0.5.2"],\
+            ["cosmjs-types", "npm:0.6.0"],\
             ["eslint", "npm:7.26.0"],\
             ["eslint-config-prettier", "virtual:4f1584ad4aba8733a24be7c8aebbffafef25607f2d00f4b314cf96717145c692763628a31c2b85d4686fbb091ff21ebffa3cc337399c042c19a32b9bdb786464#npm:8.3.0"],\
             ["eslint-import-resolver-node", "npm:0.3.4"],\
@@ -6919,10 +6919,10 @@ function $$SETUP_STATE(hydrateRuntimeState, basePath) {
         }]\
       ]],\
       ["cosmjs-types", [\
-        ["npm:0.5.2", {\
-          "packageLocation": "./.yarn/cache/cosmjs-types-npm-0.5.2-cf7bc203f4-0362cb2136.zip/node_modules/cosmjs-types/",\
+        ["npm:0.6.0", {\
+          "packageLocation": "./.yarn/cache/cosmjs-types-npm-0.6.0-4ad2730ce2-06000f10d9.zip/node_modules/cosmjs-types/",\
           "packageDependencies": [\
-            ["cosmjs-types", "npm:0.5.2"],\
+            ["cosmjs-types", "npm:0.6.0"],\
             ["long", "npm:4.0.0"],\
             ["protobufjs", "npm:6.11.3"]\
           ],\
diff --git a/.yarn/cache/cosmjs-types-npm-0.5.2-cf7bc203f4-0362cb2136.zip b/.yarn/cache/cosmjs-types-npm-0.5.2-cf7bc203f4-0362cb2136.zip
deleted file mode 100644
index b0deca0454..0000000000
--- a/.yarn/cache/cosmjs-types-npm-0.5.2-cf7bc203f4-0362cb2136.zip
+++ /dev/null
@@ -1,3 +0,0 @@
-version https://git-lfs.github.com/spec/v1
-oid sha256:280e5b09cb88ffb16c89e8dc357810c9578d42abd3e730c1014b04de8a75756f
-size 1116655
diff --git a/.yarn/cache/cosmjs-types-npm-0.6.0-4ad2730ce2-06000f10d9.zip b/.yarn/cache/cosmjs-types-npm-0.6.0-4ad2730ce2-06000f10d9.zip
new file mode 100644
index 0000000000..b6ae462ed8
--- /dev/null
+++ b/.yarn/cache/cosmjs-types-npm-0.6.0-4ad2730ce2-06000f10d9.zip
@@ -0,0 +1,3 @@
+version https://git-lfs.github.com/spec/v1
+oid sha256:481f034b96a9167980596c7db0958e8058782276b6ef965462ecdc127ab24a4f
+size 939388
diff --git a/CHANGELOG.md b/CHANGELOG.md
index d82201ed2e..465110ae9d 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -22,11 +22,15 @@ and this project adheres to
   `createStakingAminoConverters`. This made `prefix` in
   `SigningCosmWasmClientOptions` and `SigningStargateClientOptions` obsolete, so
   this was also deleted. ([#1291])
+- @cosmjs/proto-signing: Remove `fromJSON`/`toJSON` from `TsProtoGeneratedType`
+  such that generated types are not required to generate those anymore. The
+  methods were provided by ts-proto but we never needed them. ([#1329])
 
 [#1002]: https://github.com/cosmos/cosmjs/issues/1002
 [#1240]: https://github.com/cosmos/cosmjs/pull/1240
 [#1289]: https://github.com/cosmos/cosmjs/issues/1289
 [#1291]: https://github.com/cosmos/cosmjs/issues/1291
+[#1329]: https://github.com/cosmos/cosmjs/pull/1329
 [#1341]: https://github.com/cosmos/cosmjs/issues/1341
 
 ## [0.29.5] - 2022-12-07
diff --git a/packages/cli/package.json b/packages/cli/package.json
index cfdd2924a0..4f37d7cb3b 100644
--- a/packages/cli/package.json
+++ b/packages/cli/package.json
@@ -53,7 +53,7 @@
     "axios": "^0.21.2",
     "babylon": "^6.18.0",
     "chalk": "^4",
-    "cosmjs-types": "^0.5.2",
+    "cosmjs-types": "^0.6.0",
     "diff": "^4",
     "recast": "^0.20",
     "ts-node": "^8",
diff --git a/packages/cosmwasm-stargate/package.json b/packages/cosmwasm-stargate/package.json
index e2721bf08c..3272bc67a6 100644
--- a/packages/cosmwasm-stargate/package.json
+++ b/packages/cosmwasm-stargate/package.json
@@ -46,7 +46,7 @@
     "@cosmjs/stargate": "workspace:^",
     "@cosmjs/tendermint-rpc": "workspace:^",
     "@cosmjs/utils": "workspace:^",
-    "cosmjs-types": "^0.5.2",
+    "cosmjs-types": "^0.6.0",
     "long": "^4.0.0",
     "pako": "^2.0.2"
   },
diff --git a/packages/cosmwasm-stargate/src/signingcosmwasmclient.spec.ts b/packages/cosmwasm-stargate/src/signingcosmwasmclient.spec.ts
index 20ef4702ec..fac9198078 100644
--- a/packages/cosmwasm-stargate/src/signingcosmwasmclient.spec.ts
+++ b/packages/cosmwasm-stargate/src/signingcosmwasmclient.spec.ts
@@ -14,7 +14,8 @@ import {
   MsgSendEncodeObject,
 } from "@cosmjs/stargate";
 import { assert, sleep } from "@cosmjs/utils";
-import { DeepPartial, MsgSend } from "cosmjs-types/cosmos/bank/v1beta1/tx";
+import { DeepPartial } from "cosmjs-types";
+import { MsgSend } from "cosmjs-types/cosmos/bank/v1beta1/tx";
 import { Coin } from "cosmjs-types/cosmos/base/v1beta1/coin";
 import { MsgDelegate } from "cosmjs-types/cosmos/staking/v1beta1/tx";
 import { AuthInfo, TxBody, TxRaw } from "cosmjs-types/cosmos/tx/v1beta1/tx";
@@ -878,10 +879,6 @@ describe("SigningCosmWasmClient", () => {
             throw new Error("decode method should not be required");
           },
 
-          fromJSON(): CustomMsgDelegate {
-            throw new Error("fromJSON method should not be required");
-          },
-
           fromPartial(object: DeepPartial<CustomMsgDelegate>): CustomMsgDelegate {
             const message = { ...baseCustomMsgDelegate } as CustomMsgDelegate;
             if (object.customDelegatorAddress !== undefined && object.customDelegatorAddress !== null) {
@@ -901,10 +898,6 @@ describe("SigningCosmWasmClient", () => {
             }
             return message;
           },
-
-          toJSON(): unknown {
-            throw new Error("toJSON method should not be required");
-          },
         };
         customRegistry.register(msgDelegateTypeUrl, CustomMsgDelegate);
         const customAminoTypes = new AminoTypes({
@@ -1177,10 +1170,6 @@ describe("SigningCosmWasmClient", () => {
             throw new Error("decode method should not be required");
           },
 
-          fromJSON(): CustomMsgDelegate {
-            throw new Error("fromJSON method should not be required");
-          },
-
           fromPartial(object: DeepPartial<CustomMsgDelegate>): CustomMsgDelegate {
             const message = { ...baseCustomMsgDelegate } as CustomMsgDelegate;
             if (object.customDelegatorAddress !== undefined && object.customDelegatorAddress !== null) {
@@ -1200,10 +1189,6 @@ describe("SigningCosmWasmClient", () => {
             }
             return message;
           },
-
-          toJSON(): unknown {
-            throw new Error("toJSON method should not be required");
-          },
         };
         customRegistry.register(msgDelegateTypeUrl, CustomMsgDelegate);
         const customAminoTypes = new AminoTypes({
diff --git a/packages/proto-signing/package.json b/packages/proto-signing/package.json
index 4af55f14f2..fef1d589f3 100644
--- a/packages/proto-signing/package.json
+++ b/packages/proto-signing/package.json
@@ -44,7 +44,7 @@
     "@cosmjs/encoding": "workspace:^",
     "@cosmjs/math": "workspace:^",
     "@cosmjs/utils": "workspace:^",
-    "cosmjs-types": "^0.5.2",
+    "cosmjs-types": "^0.6.0",
     "long": "^4.0.0"
   },
   "devDependencies": {
diff --git a/packages/proto-signing/src/registry.ts b/packages/proto-signing/src/registry.ts
index 5be89db54f..503f7abe7d 100644
--- a/packages/proto-signing/src/registry.ts
+++ b/packages/proto-signing/src/registry.ts
@@ -12,9 +12,10 @@ import type protobuf from "protobufjs";
 export interface TsProtoGeneratedType {
   readonly encode: (message: any | { [k: string]: any }, writer?: protobuf.Writer) => protobuf.Writer;
   readonly decode: (input: Uint8Array | protobuf.Reader, length?: number) => any;
-  readonly fromJSON: (object: any) => any;
   readonly fromPartial: (object: any) => any;
-  readonly toJSON: (message: any | { [k: string]: any }) => unknown;
+  // Methods from ts-proto types we don't need
+  // readonly fromJSON: (object: any) => any;
+  // readonly toJSON: (message: any | { [k: string]: any }) => unknown;
 }
 
 /**
diff --git a/packages/stargate/package.json b/packages/stargate/package.json
index 2a9ef6ecf3..d749e6df70 100644
--- a/packages/stargate/package.json
+++ b/packages/stargate/package.json
@@ -46,7 +46,7 @@
     "@cosmjs/stream": "workspace:^",
     "@cosmjs/tendermint-rpc": "workspace:^",
     "@cosmjs/utils": "workspace:^",
-    "cosmjs-types": "^0.5.2",
+    "cosmjs-types": "^0.6.0",
     "long": "^4.0.0",
     "protobufjs": "~6.11.3",
     "xstream": "^11.14.0"
diff --git a/packages/stargate/src/accounts.spec.ts b/packages/stargate/src/accounts.spec.ts
index f4010d2e09..62d604436b 100644
--- a/packages/stargate/src/accounts.spec.ts
+++ b/packages/stargate/src/accounts.spec.ts
@@ -1,3 +1,4 @@
+import { fromBase64 } from "@cosmjs/encoding";
 import { Any } from "cosmjs-types/google/protobuf/any";
 
 import { accountFromAny } from "./accounts";
@@ -6,10 +7,11 @@ describe("accounts", () => {
   describe("accountFromAny", () => {
     it("works for PeriodicVestingAccount", () => {
       // Queried from chain via `packages/cli/examples/get_akash_vesting_account.ts`.
-      const any = Any.fromJSON({
+      const any = Any.fromPartial({
         typeUrl: "/cosmos.vesting.v1beta1.PeriodicVestingAccount",
-        value:
+        value: fromBase64(
           "CsMBCnoKLGFrYXNoMXF5MHZ1cjNmbDJ1Y3p0cHpjcmZlYTdtYzhqd3o4eGptdnE3cXZ5EkYKHy9jb3Ntb3MuY3J5cHRvLnNlY3AyNTZrMS5QdWJLZXkSIwohA/XsdhwSIKU73TltD9STcaS07FNw0szR4a+oDLr6vikaGDggGxIUCgR1YWt0EgwxNjY2NjY2NzAwMDAaEwoEdWFrdBILMzcxOTAzMzAwMDAiFAoEdWFrdBIMMTY2NjY2NjcwMDAwKOC9wZkGEODvt/sFGhoIgOeEDxITCgR1YWt0Egs4MzMzMzMzNTAwMBoaCIC/ugcSEwoEdWFrdBILNDE2NjY2Njc1MDAaGgiAqMoHEhMKBHVha3QSCzQxNjY2NjY3NTAw",
+        ),
       });
 
       const account = accountFromAny(any);
diff --git a/packages/stargate/src/signingstargateclient.spec.ts b/packages/stargate/src/signingstargateclient.spec.ts
index a138e3e40a..e0a58e2b8e 100644
--- a/packages/stargate/src/signingstargateclient.spec.ts
+++ b/packages/stargate/src/signingstargateclient.spec.ts
@@ -10,11 +10,12 @@ import {
 } from "@cosmjs/proto-signing";
 import { Tendermint34Client } from "@cosmjs/tendermint-rpc";
 import { assert, sleep } from "@cosmjs/utils";
+import { DeepPartial } from "cosmjs-types";
 import { MsgSend } from "cosmjs-types/cosmos/bank/v1beta1/tx";
 import { Coin } from "cosmjs-types/cosmos/base/v1beta1/coin";
 import { BasicAllowance } from "cosmjs-types/cosmos/feegrant/v1beta1/feegrant";
 import { MsgGrantAllowance } from "cosmjs-types/cosmos/feegrant/v1beta1/tx";
-import { DeepPartial, MsgDelegate } from "cosmjs-types/cosmos/staking/v1beta1/tx";
+import { MsgDelegate } from "cosmjs-types/cosmos/staking/v1beta1/tx";
 import { AuthInfo, TxBody, TxRaw } from "cosmjs-types/cosmos/tx/v1beta1/tx";
 import { Any } from "cosmjs-types/google/protobuf/any";
 import Long from "long";
@@ -541,10 +542,6 @@ describe("SigningStargateClient", () => {
             throw new Error("decode method should not be required");
           },
 
-          fromJSON(): CustomMsgDelegate {
-            throw new Error("fromJSON method should not be required");
-          },
-
           fromPartial(object: DeepPartial<CustomMsgDelegate>): CustomMsgDelegate {
             const message = { ...baseCustomMsgDelegate } as CustomMsgDelegate;
             if (object.customDelegatorAddress !== undefined && object.customDelegatorAddress !== null) {
@@ -564,10 +561,6 @@ describe("SigningStargateClient", () => {
             }
             return message;
           },
-
-          toJSON(): unknown {
-            throw new Error("toJSON method should not be required");
-          },
         };
         customRegistry.register(msgDelegateTypeUrl, CustomMsgDelegate);
         const customAminoTypes = new AminoTypes({
@@ -829,10 +822,6 @@ describe("SigningStargateClient", () => {
             throw new Error("decode method should not be required");
           },
 
-          fromJSON(): CustomMsgDelegate {
-            throw new Error("fromJSON method should not be required");
-          },
-
           fromPartial(object: DeepPartial<CustomMsgDelegate>): CustomMsgDelegate {
             const message = { ...baseCustomMsgDelegate } as CustomMsgDelegate;
             if (object.customDelegatorAddress !== undefined && object.customDelegatorAddress !== null) {
@@ -852,10 +841,6 @@ describe("SigningStargateClient", () => {
             }
             return message;
           },
-
-          toJSON(): unknown {
-            throw new Error("toJSON method should not be required");
-          },
         };
         customRegistry.register(msgDelegateTypeUrl, CustomMsgDelegate);
         const customAminoTypes = new AminoTypes({
diff --git a/yarn.lock b/yarn.lock
index e017631232..bb20339ff6 100644
--- a/yarn.lock
+++ b/yarn.lock
@@ -362,7 +362,7 @@ __metadata:
     axios: ^0.21.2
     babylon: ^6.18.0
     chalk: ^4
-    cosmjs-types: ^0.5.2
+    cosmjs-types: ^0.6.0
     diff: ^4
     eslint: ^7.5
     eslint-config-prettier: ^8.3.0
@@ -408,7 +408,7 @@ __metadata:
     "@types/pako": ^1.0.1
     "@typescript-eslint/eslint-plugin": ^5.13.0
     "@typescript-eslint/parser": ^5.13.0
-    cosmjs-types: ^0.5.2
+    cosmjs-types: ^0.6.0
     eslint: ^7.5
     eslint-config-prettier: ^8.3.0
     eslint-import-resolver-node: ^0.3.4
@@ -767,7 +767,7 @@ __metadata:
     "@types/node": ^15.0.1
     "@typescript-eslint/eslint-plugin": ^5.13.0
     "@typescript-eslint/parser": ^5.13.0
-    cosmjs-types: ^0.5.2
+    cosmjs-types: ^0.6.0
     eslint: ^7.5
     eslint-config-prettier: ^8.3.0
     eslint-import-resolver-node: ^0.3.4
@@ -864,7 +864,7 @@ __metadata:
     "@types/node": ^15.0.1
     "@typescript-eslint/eslint-plugin": ^5.13.0
     "@typescript-eslint/parser": ^5.13.0
-    cosmjs-types: ^0.5.2
+    cosmjs-types: ^0.6.0
     eslint: ^7.5
     eslint-config-prettier: ^8.3.0
     eslint-import-resolver-node: ^0.3.4
@@ -2929,13 +2929,13 @@ __metadata:
   languageName: unknown
   linkType: soft
 
-"cosmjs-types@npm:^0.5.2":
-  version: 0.5.2
-  resolution: "cosmjs-types@npm:0.5.2"
+"cosmjs-types@npm:^0.6.0":
+  version: 0.6.0
+  resolution: "cosmjs-types@npm:0.6.0"
   dependencies:
     long: ^4.0.0
     protobufjs: ~6.11.2
-  checksum: 0362cb2136a17c0f91f0727a55a1f49058bb56665136cf88e4502febf6da59fa2d4ce91ed75bc55907571b9f1cd99546d594002509781b69fe71fe972dbfe4c1
+  checksum: 06000f10d931bbd23381a2303337f6c203add988d2e4e63307a0b920b2c317197d3e17d4fc535e55e7fdc211e472ee3dff18847bb7f42704d194370a1c6ed581
   languageName: node
   linkType: hard